HYPOGLYCEMIC ACTIVITY OF $ORIGANUM~VULGARE$ L. AQUEOUS EXTRACT IN HYPERGLYCEMIA INDUCED BY IMMOBILIZATION STRESS IN RABBITS

Currently diabetes mellitus (DM) is a worldwide problem linked to hyper-glyce¬mia and has affected people both in developing developed countries. DM divided into Type 1 (T1DM) 2 (T2DM). Moreover, the T2DM most prevalence form that encompasses reduce responsiveness insulin-sensitive cells or defects insulin secretion. Exposure chronic immobilization stress contributes development of hyperglycemia hyperlipidemia can lead cardiovascular complications. Herbs with hypoglycemic properties, especially Origanum vulgare L., would be useful treatment. Oral administration aqueous extract showed significant effect on improving glucose tolerance. In addition, O. reduced total cholesterol, low-density lipoprotein cholesterol levels, vice versa increased high-density also decreased liver enzymes levels (alanine aminotransferase aspartate aminotransferase) compared untreated group might recommended as herbal remedy treatment stress-induced hyperglycemia.